Kết quả phiên chạy FP4 của chặng đua MotoGP Americas 2021:
| Stt | Tay đua | Xe | Km/h | Thời gian | Kh/cách |
| 1 | Jack MILLER | Ducati | 347.2 | 2’04.028 | |
| 2 | Joan MIR | Suzuki | 339.6 | 2’04.180 | 0.152 / 0.152 |
| 3 | Francesco BAGNAIA | Ducati | 347.2 | 2’04.355 | 0.327 / 0.175 |
| 4 | Johann ZARCO | Ducati | 349.5 | 2’04.375 | 0.347 / 0.020 |
| 5 | Fabio QUARTARARO | Yamaha | 337.5 | 2’04.379 | 0.351 / 0.004 |
| 6 | Takaaki NAKAGAMI | Honda | 342.8 | 2’04.404 | 0.376 / 0.025 |
| 7 | Alex RINS | Suzuki | 339.6 | 2’04.462 | 0.434 / 0.058 |
| 8 | Marc MARQUEZ | Honda | 341.7 | 2’04.544 | 0.516 / 0.082 |
| 9 | Miguel OLIVEIRA | KTM | 340.6 | 2’04.711 | 0.683 / 0.167 |
| 10 | Aleix ESPARGARO | Aprilia | 343.9 | 2’04.711 | 0.683 |
| 11 | Luca MARINI | Ducati | 337.5 | 2’05.049 | 1.021 / 0.338 |
| 12 | Enea BASTIANINI | Ducati | 347.2 | 2’05.071 | 1.043 / 0.022 |
| 13 | Jorge MARTIN | Ducati | 346.1 | 2’05.215 | 1.187 / 0.144 |
| 14 | Brad BINDER | KTM | 343.9 | 2’05.312 | 1.284 / 0.097 |
| 15 | Andrea DOVIZIOSO | Yamaha | 337.5 | 2’05.349 | 1.321 / 0.037 |
| 16 | Alex MARQUEZ | Honda | 345.0 | 2’05.407 | 1.379 / 0.058 |
| 17 | Pol ESPARGARO | Honda | 343.9 | 2’05.429 | 1.401 / 0.022 |
| 18 | Valentino ROSSI | Yamaha | 336.4 | 2’05.551 | 1.523 / 0.122 |
| 19 | Iker LECUONA | KTM | 341.7 | 2’05.566 | 1.538 / 0.015 |
| 20 | Franco MORBIDELLI | Yamaha | 335.4 | 2’05.614 | 1.586 / 0.048 |
| 21 | Danilo PETRUCCI | KTM | 340.6 | 2’06.185 | 2.157 / 0.571 |
Nguồn: Tổng hợp
