Kết quả phiên chạy FP2 của chặng đua MotoGP San Marino 2021:
| Stt | Tay đua | Xe | Km/h | Thời gian | Kh/cách |
| 1 | Johann ZARCO | Ducati | 291.8 | 1’42.097 | |
| 2 | Francesco BAGNAIA | Ducati | 290.3 | 1’42.650 | 0.553 / 0.553 |
| 3 | Jack MILLER | Ducati | 288.7 | 1’42.719 | 0.622 / 0.069 |
| 4 | Joan MIR | Suzuki | 283.4 | 1’42.910 | 0.813 / 0.191 |
| 5 | Marc MARQUEZ | Honda | 285.7 | 1’42.921 | 0.824 / 0.011 |
| 6 | Miguel OLIVEIRA | KTM | 282.7 | 1’43.234 | 1.137 / 0.313 |
| 7 | Danilo PETRUCCI | KTM | 285.7 | 1’43.329 | 1.232 / 0.095 |
| 8 | Aleix ESPARGARO | Aprilia | 286.4 | 1’43.629 | 1.532 / 0.300 |
| 9 | Iker LECUONA | KTM | 281.2 | 1’43.722 | 1.625 / 0.093 |
| 10 | Alex MARQUEZ | Honda | 288.0 | 1’43.739 | 1.642 / 0.017 |
| 11 | Alex RINS | Suzuki | 287.2 | 1’43.760 | 1.663 / 0.021 |
| 12 | Michele PIRRO | Ducati | 281.9 | 1’43.811 | 1.714 / 0.051 |
| 13 | Franco MORBIDELLI | Yamaha | 279.7 | 1’43.844 | 1.747 / 0.033 |
| 14 | Enea BASTIANINI | Ducati | 281.9 | 1’43.901 | 1.804 / 0.057 |
| 15 | Jorge MARTIN | Ducati | 289.5 | 1’43.906 | 1.809 / 0.005 |
| 16 | Valentino ROSSI | Yamaha | 283.4 | 1’44.130 | 2.033 / 0.224 |
| 17 | Maverick VIÑALES | Aprilia | 286.4 | 1’44.203 | 2.106 / 0.073 |
| 18 | Fabio QUARTARARO | Yamaha | 282.7 | 1’44.205 | 2.108 / 0.002 |
| 19 | Pol ESPARGARO | Honda | 287.2 | 1’44.266 | 2.169 / 0.061 |
| 20 | Brad BINDER | KTM | 281.2 | 1’44.404 | 2.307 / 0.138 |
| 21 | Andrea DOVIZIOSO | Yamaha | 279.0 | 1’44.530 | 2.433 / 0.126 |
| 22 | Stefan BRADL | Honda | 284.2 | 1’44.713 | 2.616 / 0.183 |
| 23 | Luca MARINI | Ducati | 280.5 | 1’44.970 | 2.873 / 0.257 |
| 24 | Takaaki NAKAGAMI | Honda | 281.2 | 1’44.992 | 2.895 / 0.022 |
Nguồn: Tổng hợp
