Kết quả phiên chạy FP2 của chặng đua GP Sao Paulo 2021:
| stt | Tay đua | xe | Thời gian | Kh/cách | Lap |
| 1 | Fernando Alonso | ALPINE | 1:11.238 | 23 | |
| 2 | Max Verstappen | RED BULL | 1:12.102 | +0.864s | 26 |
| 3 | Valtteri Bottas | MERCEDES | 1:12.355 | +1.117s | 24 |
| 4 | Esteban Ocon | ALPINE | 1:12.407 | +1.169s | 26 |
| 5 | Lewis Hamilton | MERCEDES | 1:12.741 | +1.503s | 25 |
| 6 | Sergio Perez | RED BULL | 1:12.903 | +1.665s | 29 |
| 7 | Antonio Giovinazzi | ALFA ROMEO | 1:12.997 | +1.759s | 37 |
| 8 | Carlos Sainz | FERRARI | 1:13.078 | +1.840s | 31 |
| 9 | Charles Leclerc | FERRARI | 1:13.099 | +1.861s | 33 |
| 10 | Kimi Räikkönen | ALFA ROMEO | 1:13.355 | +2.117s | 39 |
| 11 | Lance Stroll | ASTON MARTIN | 1:13.426 | +2.188s | 41 |
| 12 | Daniel Ricciardo | MCLAREN | 1:13.448 | +2.210s | 25 |
| 13 | Lando Norris | MCLAREN | 1:13.581 | +2.343s | 23 |
| 14 | Pierre Gasly | ALPHATAURI | 1:13.608 | +2.370s | 32 |
| 15 | George Russell | WILLIAMS | 1:13.615 | +2.377s | 24 |
| 16 | Yuki Tsunoda | ALPHATAURI | 1:13.726 | +2.488s | 38 |
| 17 | Sebastian Vettel | ASTON MARTIN | 1:13.747 | +2.509s | 42 |
| 18 | Nicholas Latifi | WILLIAMS | 1:14.025 | +2.787s | 24 |
| 19 | Mick Schumacher | HAAS | 1:14.066 | +2.828s | 40 |
| 20 | Nikita Mazepin | HAAS | 1:14.909 | +3.671s | 37 |
Nguồn: Tổng hợp
