Kết quả phiên chạy FP2 của chặng đua GP Mỹ 2021:
| Stt | Tay đua | Xe | Thời gian | Kh/cách | LAP |
| 1 | Sergio Perez | RED BULL | 1:34.946 | 24 | |
| 2 | Lando Norris | MCLAREN | 1:35.203 | +0.257s | 20 |
| 3 | Lewis Hamilton | MERCEDES | 1:35.310 | +0.364s | 22 |
| 4 | Valtteri Bottas | MERCEDES | 1:35.360 | +0.414s | 24 |
| 5 | Daniel Ricciardo | MCLAREN | 1:35.457 | +0.511s | 21 |
| 6 | Lance Stroll | ASTON MARTIN | 1:35.561 | +0.615s | 25 |
| 7 | Charles Leclerc | FERRARI | 1:35.572 | +0.626s | 23 |
| 8 | Max Verstappen | RED BULL | 1:35.824 | +0.878s | 23 |
| 9 | Carlos Sainz | FERRARI | 1:35.919 | +0.973s | 24 |
| 10 | Antonio Giovinazzi | ALFA ROMEO | 1:36.138 | +1.192s | 26 |
| 11 | Esteban Ocon | ALPINE | 1:36.158 | +1.212s | 23 |
| 12 | Pierre Gasly | ALPHATAURI | 1:36.242 | +1.296s | 25 |
| 13 | Fernando Alonso | ALPINE | 1:36.376 | +1.430s | 18 |
| 14 | Kimi Räikkönen | ALFA ROMEO | 1:36.558 | +1.612s | 25 |
| 15 | Sebastian Vettel | ASTON MARTIN | 1:36.718 | +1.772s | 30 |
| 16 | Yuki Tsunoda | ALPHATAURI | 1:36.983 | +2.037s | 24 |
| 17 | Mick Schumacher | HAAS | 1:37.041 | +2.095s | 24 |
| 18 | Nicholas Latifi | WILLIAMS | 1:37.254 | +2.308s | 26 |
| 19 | George Russell | WILLIAMS | 1:37.490 | +2.544s | 21 |
| 20 | Nikita Mazepin | HAAS | 1:38.026 | +3.080s | 23 |
Nguồn: Tổng hợp
